Cities Building Community Wealth

As cities struggle with rising inequality, widespread economic hardship, and racial disparities, something surprising and hopeful is also stirring. In a growing number of America's cities, a more inclusive, community-based approach to economic development is being taken up by a new breed of economic development professionals and mayors. This approach to economic development could be on the cusp of going to scale. It's time it had a name. We call it community wealth building

A New Anchor Mission for a New Century: Community Foundations Deploying all Resources to Build Community Wealth

A new report examines how leading community foundations are embracing an anchor mission to build stronger local economies and invest more resources in the communities they serve. According to the report, community foundations are "anchor institutions" -- place-based nonprofits with significant resources that are highly unlikely to abandon the communities in which they reside. With many of these communities in both rural and urban areas struggling with deeply entrenched economic problems like inequality and unemployment, the case becomes clear for community foundations to take up the "anchor mission": recognizing the impact they can have as engines of community economic development and local mission-driven investment

Control de inventarios y su relación con la rentabilidad de la empresa Fabricaciones Montajes y Servicios S.A.C., distrito Ate, 2021

Desde hace mucho tiempo en el Perú, las empresas comercializadoras o las prestadoras de servicios utilizaron almacenes para custodiar sus herramientas, materiales, productos y demás bienes, para lo cual utilizaron métodos que les permitieron medir el stock mínimo buscando satisfacer al cliente y multiplicando sus ganancias. El objetivo de este estudio ha sido identificar la relación que existió entre el control de inventarios y la rentabilidad económica y financiera tomándose como referencia una empresa de la capital limeña. Durante el desarrollo de este estudio se identificaron diversos métodos y procedimientos de medición de diversos autores; y se obtuvo datos importantes de las encuestas que se realizó a los trabajadores. Confirmando al final que nuestra hipótesis si presentó una correlación entre las variables de muy baja y moderada, a la vez se hallaron una falencia en los sobrecostos de importación de motores. Se concluyó que la empresa generó mayores ingresos por los servicios prestados que, por la importación de motores. Sin embargo, el buen manejo de los inventarios también ayudó a obtener utilidades, así como puede ayudar a reducir los costos innecesarios provenientes de diversos factores relacionados a las existencias

The role of environment in galaxy evolution in the SERVS survey I: density maps and cluster candidates

We use photometric redshifts derived from new $u$-band through 4.5$\mu$m Spitzer IRAC photometry in the 4.8\,deg$^2$ of the XMM-LSS field to construct surface density maps in the redshift range 0.1-1.5. Our density maps show evidence for large-scale structure in the form of filaments spanning several tens of Mpc. Using these maps, we identify 339 overdensities that our simulated lightcone analysis suggests are likely associated with dark matter haloes with masses, $M_{\rm halo}$, log($M_{\rm halo}/M_{\odot})>$13.7. From this list of overdensities we recover 43 of 70 known X-ray detected and spectroscopically confirmed clusters. The missing X-ray clusters are largely at lower redshifts and lower masses than our target log($M_{\rm halo}/M_{\odot})>$13.7. The bulk of the overdensities are compact, but a quarter show extended morphologies which include likely projection effects, clusters embedded in apparent filaments as well as at least one potential cluster merger (at $z\sim1.28$). The strongest overdensity in our highest redshift slice (at $z\sim1.5$) shows a compact red galaxy core potentially implying a massive evolved cluster

Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies.

© The Author(s) 2018. Published by Oxford University Press. All rights reserved. SOX8 is an HMG-box transcription factor closely related to SRY and SOX9. Deletion of the gene encoding Sox8 in mice causes reproductive dysfunction but the role of SOX8 in humans is unknown. Here, we show that SOX8 is expressed in the somatic cells of the early developing gonad in the human and influences human sex determination. We identified two individuals with 46, XY disorders/differences in sex development (DSD) and chromosomal rearrangements encompassing the SOX8 locus and a third individual with 46, XY DSD and a missense mutation in the HMG-box of SOX8. In vitro functional assays indicate that this mutation alters the biological activity of the protein. As an emerging body of evidence suggests that DSDs and infertility can have common etiologies, we also analysed SOX8 in a cohort of infertile men (n=274) and two independent cohorts of women with primary ovarian insufficiency (POI; n=153 and n=104). SOX8 mutations were found at increased frequency in oligozoospermic men (3.5%; P < 0.05) and POI (5.06%; P=4.5×10 -5 ) as compared with fertile/normospermic control populations (0.74%). The mutant proteins identified altered SOX8 biological activity as compared with the wild-type protein. These data demonstrate that SOX8 plays an important role in human reproduction and SOX8 mutations contribute to a spectrum of phenotypes including 46, XY DSD, male infertility and 46, XX POI.Link_to_subscribed_fulltex

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

A Spitzer survey of Deep Drilling Fields to be targeted by the Vera C. Rubin Observatory Legacy Survey of Space and Time

The Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will observe several Deep Drilling Fields (DDFs) to a greater depth and with a more rapid cadence than the main survey. In this paper, we describe the 'DeepDrill' survey, which used the Spitzer Space Telescope Infrared Array Camera (IRAC) to observe three of the four currently defined DDFs in two bands, centred on 3.6 and 4.5 μm. These observations expand the area that was covered by an earlier set of observations in these three fields by the Spitzer Extragalactic Representative Volume Survey (SERVS). The combined DeepDrill and SERVS data cover the footprints of the LSST DDFs in the Extended Chandra Deep Field-South (ECDFS) field, the ELAIS-S1 field (ES1), and the XMM-Large-Scale Structure Survey field (XMM-LSS). The observations reach an approximate 5σ point-source depth of 2 μJy (corresponding to an AB magnitude of 23.1; sufficient to detect a 1011 M⊙ galaxy out to z ≈ 5) in each of the two bands over a total area of ≈ 29 deg2. The dual-band catalogues contain a total of 2.35 million sources. In this paper, we describe the observations and data products from the survey, and an overview of the properties of galaxies in the survey. We compare the source counts to predictions from the Shark semi-analytic model of galaxy formation. We also identify a population of sources with extremely red ([3.6]-[4.5] >1.2) colours which we show mostly consists of highly obscured active galactic nuclei